反応 #359814

反応方程式

2,4-Dichloro-5-iodo-pyrimidine

triethylamine

(R)-2-Amino-3-methyl-butan-1-ol

→

(R)-2-(2-Chloro-5-iodo-pyrimidin-4-ylamino)-3-methyl-butan-1-ol

溶媒

acetonitrile

water

反応条件

後処理

1. 1
   ろ過The batch is filtered
2. 2
   洗浄the solid is washed with small amounts of acetonitrile and water
3. 3
   その他The solid is dried
4. 4
   その他10.24 g (30.0 mmol, corresponding to 82% of theory) of the product is obtained

実験手順

A solution of 10.05 g (36.6 mmol) of 2,4-Dichloro-5-iodo-pyrimidine and 5.6 ml (40.0 mmol) triethylamine in 30 ml of acetonitrile is mixed with 4.85 g (47.0 mmol) of (R)-2-Amino-3-methyl-butan-1-ol. The batch is stirred at room temperature for 16 hours and is finally diluted with water. The batch is filtered and the solid is washed with small amounts of acetonitrile and water. The solid is dried. 10.24 g (30.0 mmol, corresponding to 82% of theory) of the product is obtained.

出典