反応 #359739

反応方程式

bromomethyl cyclopropane

4-piperidone hydrate hydrochloride

sodium carbonate

→

title compound

収率 55.3%

1-Cyclopropylmethyl-piperidin-4-one

収率 55.3%

溶媒

acetonitrile

反応条件

後処理

1. 1
   ろ過The resulting suspension was filtered
2. 2
   洗浄the solid was washed with acetonitrile
3. 3
   濃縮The filtrate was concentrated in vacuo
4. 4
   その他purified by column chromatography on silica eluting with DCM/2N NH3 in methanol 97:3

実験手順

To a suspension of bromomethyl cyclopropane (4 mmol) and 4-piperidone hydrate hydrochloride (4 mmol) in acetonitrile (30 mL) was added sodium carbonate (11 mmol). The reaction mixture was stirred 16 h at 85° C. The resulting suspension was filtered and the solid was washed with acetonitrile. The filtrate was concentrated in vacuo and purified by column chromatography on silica eluting with DCM/2N NH3 in methanol 97:3 to yield 339 mg of the title compound as yellow oil. MS (m/e): 154.2 (MH+, 100%).

出典