反応 #3593

反応方程式

4-[(2-methylbenzoyl)amino]benzoic acid

thionyl chloride

→

desired product

4-[(2-Methylbenzoyl)amino]benzoyl chloride

反応条件

後処理

1. 1
   温度is refluxed for 1.5 hours
2. 2
   濃縮The solution is concentrated in vacuo
3. 3
   workup.ADDITIONToluene is added
4. 4
   その他the solvent removed in vacuo
5. 5
   workup.ADDITIONToluene is added
6. 6
   温度the mixture chilled
7. 7
   ろ過filtered

実験手順

A mixture of 10.3 g of 4-[(2-methylbenzoyl)amino]benzoic acid and 32 ml of thionyl chloride is refluxed for 1.5 hours. The solution is concentrated in vacuo. Toluene is added and the solvent removed in vacuo. Toluene is added and the mixture chilled and filtered to give the desired product as a yellow solid, 135°-141° C.

出典