反応 #358505

反応方程式

2,6-dichloro-4-cyanobenzoic acid methylester

azidotributyltin

→

title compound

2,6-dichloro-4-tetrazolylbenzoic Acid Methylester

溶媒

toluene

反応条件

後処理

1. 1
   濃縮The reaction mixture was concentrated
2. 2
   workup.ADDITIONdiluted with ethyl acetate
3. 3
   ろ過After Celite filtration
4. 4
   濃縮the filtrate was concentrated
5. 5
   その他the residue was purified by reverse phase HPLC

実験手順

The mixture of 185 mg of 2,6-dichloro-4-cyanobenzoic acid methylester, 266 mg of azidotributyltin and 5 ml of toluene was stirred at 100° C. for 3 days. The reaction mixture was concentrated and diluted with ethyl acetate. After Celite filtration, the filtrate was concentrated and the residue was purified by reverse phase HPLC to obtain the title compound.

出典