反応 #357824

反応方程式

sodium boron hydride

lithium bromide

compound

methyl 2-methoxycarbonylmethylthiophen-3-carboxylate

trimethyl borate

→

title compound

収率 90.6%

2-(3-hydroxymethylthiophen-2-yl)ethanol

収率 90.6%

溶媒

tetrahydrofuran

water

ethyl ether

methanol

tetrahydrofuran

反応条件

後処理

1. 1
   その他dropwise at 0° C
2. 2
   その他a solution obtained
3. 3
   workup.ADDITIONwas slowly added over 2 hours
4. 4
   温度to reflux
5. 5
   温度The reaction solution was further refluxed for 2 hours
6. 6
   温度then cooled to room temperature
7. 7
   その他The organic phase was collected
8. 8
   乾燥dried over anhydrous magnesium sulfate
9. 9
   濃縮concentrated under reduced pressure

実験手順

To 800 mL of anhydrous tetrahydrofuran, 31.0 g of sodium boron hydride and 71.3 g of lithium bromide were added, and then 10.6 mL of trimethyl borate was added thereto dropwise at 0° C. The resulting mixture was stirred at room temperature for 30 minutes, and then a solution obtained by dissolving 70.4 g of the compound obtained in Example 1 in 200 mL of tetrahydrofuran was slowly added over 2 hours while allowing the resulting mixture to reflux. The reaction solution was further refluxed for 2 hours then cooled to room temperature. 100 mL of anhydrous methanol was added slowly to the solution, and then 700 mL of ethyl ether and 700 mL of water were added. The organic phase was collected, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain 47.1 g (yield of 90%) of the title compound as an oil.

出典