反応 #356891

反応方程式

potassium carbonate

4-phenylphenol

6-chloro-1-hexanol

→

4-(6-hydroxyhexyloxy)phenylbenzene

収率 85.1%

溶媒

water

DMF

N,N-dimethylformamide

反応条件

後処理

1. 1
   workup.ADDITIONwas added with constant stirring
2. 2
   workup.WAITto proceed for 12 hours under constant stirring
3. 3
   ろ過the precipitated solid was recovered by filtration
4. 4
   その他The resulting solid was then recrystallized from ethanol

実験手順

17 g of 4-phenylphenol (0.1 mol) was dissolved in 120 mL of N,N-dimethylformamide (hereafter abbreviated as DMF), 15.2 g of potassium carbonate powder (0.11 mol) was added with constant stirring, and the mixture was then stirred for one hour while heating at 90° C. Subsequently, 6-chloro-1-hexanol (14.3 g, 0.11 mol) was added dropwise to the mixture, and the reaction was allowed to proceed for 12 hours under constant stirring. Following confirmation by gas chromatography that the peaks derived from the raw materials had disappeared, the reaction mixture was diluted with water, and the precipitated solid was recovered by filtration. The resulting solid was then recrystallized from ethanol, yielding 23 g of 4-(6-hydroxyhexyloxy)phenylbenzene (yield: 85%).

出典