反応 #355750

反応方程式

5-fluoro-2-nitrotoluene

N-methylpyrrolidinone

4-amino-2-butanol

triethylamine

→

4-(4-nitro-3-methylphenylamino)butan-2-ol

収率 99.6%

溶媒

water

反応条件

後処理

1. 1
   温度after cooling to room temperature
2. 2
   抽出The resulting medium was extracted with ethyl acetate
3. 3
   濃縮the organic phase was then concentrated under vacuum

実験手順

2 g of 5-fluoro-2-nitrotoluene were added to a solution of 20 ml of N-methylpyrrolidinone, 1.38 g of 4-amino-2-butanol and 1.57 g of triethylamine. The reaction medium was heated at 60° C. for 10 hours and, after cooling to room temperature, was then poured into a water and ice mixture. The resulting medium was extracted with ethyl acetate and the organic phase was then concentrated under vacuum. 2.88 g of 4-(4-nitro-3-methylphenylamino)butan-2-ol (31) were obtained.

出典