反応 #355748

反応方程式

2-fluoro-5-nitrotoluene

N-methylpyrrolidinone

4-amino-2-butanol

triethylamine

→

4-(4-nitro-2-methylphenylamino)butan-2-ol

収率 82.3%

溶媒

water

反応条件

後処理

1. 1
   温度after cooling to room temperature
2. 2
   その他The yellow precipitate formed
3. 3
   ろ過was filtered off
4. 4
   乾燥dried over P2O5

実験手順

2 g of 2-fluoro-5-nitrotoluene were added to a solution of 20 ml of N-methylpyrrolidinone, 1.38 g of 4-amino-2-butanol and 1.57 g of triethylamine. The reaction medium was heated at 60° C. for 12 hours and, after cooling to room temperature, was then poured into a water and ice mixture. The yellow precipitate formed was filtered off, reslurried in water and then dried over P2O5. 2.38 g of 4-(4-nitro-2-methylphenylamino)butan-2-ol (27) were obtained.

出典