反応 #355740

反応方程式

2-fluoro-5-nitrotoluene

N-methylpyrrolidinone

2-aminoethoxyethanol

K2CO3

→

2-[2-(4-nitro-2-methylphenylamino)ethoxy]ethanol

溶媒

water

反応条件

後処理

1. 1
   温度after cooling to room temperature
2. 2
   抽出The resulting medium was extracted with ethyl acetate
3. 3
   濃縮the organic phase was then concentrated under vacuum

実験手順

2 g of 2-fluoro-5-nitrotoluene were added to a solution of 20 ml of N-methylpyrrolidinone, 1.63 g of 2-aminoethoxyethanol and 2.14 g of K2CO3. The reaction medium was heated at 60° C. for 12 hours and, after cooling to room temperature, was then poured into a water and ice mixture. The resulting medium was extracted with ethyl acetate and the organic phase was then concentrated under vacuum. 2.2 g of 2-[2-(4-nitro-2-methylphenylamino)ethoxy]ethanol (13) were obtained.

出典