反応 #355653

反応方程式

ethyl oxalate

sodium ethoxide

sodium

phenylacetonitrile

→

ethyl 3-cyano-3-phenylpyruvate

溶媒

ethanol

反応条件

後処理

1. 1
   workup.ADDITIONA mixture of 117.1 g
2. 2
   温度refluxed two hours
3. 3
   温度After cooling
4. 4
   workup.ADDITIONdiluting with 2500 ml
5. 5
   抽出of water and extracting with ether
6. 6
   その他The solid was removed
7. 7
   洗浄washed with water

実験手順

A mixture of 117.1 g. (1.0 mol.) of phenylacetonitrile and 326 ml. (2.4 mol.) of ethyl oxalate was added to an ethanol solution of sodium ethoxide [prepared by dissolving 23.8 g. (1.08 g.-atom) of sodium in 500 ml. of absolute ethanol] and refluxed two hours. After cooling, diluting with 2500 ml. of water and extracting with ether, the solution was acidified with acetic acid. The solid was removed and washed with water to give ethyl 3-cyano-3-phenylpyruvate, m.p. 127°-129°.

出典