反応 #3556

反応方程式

6-(2,6-dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

tert-butyl isocyanate

→

title compound

1-[2-Amino-6-(2,6-dibromo-phenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl-urea

反応条件

後処理

1. 1
   その他The product was purified by MPLC
2. 2
   洗浄eluting with a gradient of CHCl3 :EtOAc (1:1) to EtOAc
3. 3
   その他to afford the pure product

実験手順

The title compound was prepared from 0.25 g of 6-(2,6-dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 60 and 0.077 mL of tert-butyl isocyanate according to Example 2. The product was purified by MPLC eluting with a gradient of CHCl3 :EtOAc (1:1) to EtOAc to afford the pure product; mp >300° C. (dec).

出典