反応 #355210

反応方程式

2-(methylthio)-5-(o-fluorophenyl)-7-chloro-3H-1,4-benzodiazepine

diethoxyacetic acid hydrazide

→

6-(o-fluorophenyl)-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxaldehyde-diethylacetal

溶媒

hexamethylphosphoric acid triamide

反応条件

後処理

1. 1
   その他the residue recrystallised from ethyl acetate/petroleum ether

実験手順

A solution of 15.9 g of 2-(methylthio)-5-(o-fluorophenyl)-7-chloro-3H-1,4-benzodiazepine and 9.7 g of diethoxyacetic acid hydrazide in 100 ml of hexamethylphosphoric acid triamide is heated for 10 hours at 140°; processing is then carried out analogously to the procedure described in Example 1, and the residue recrystallised from ethyl acetate/petroleum ether to obtain 6-(o-fluorophenyl)-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxaldehyde-diethylacetal, M.P. 120°-121°.

出典