反応 #3552

反応方程式

6-(2,3-dichlorophenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

6-(2,3-Dichlorophenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

tert-butyl isocyanate

→

title compound

1-[2-Amino-6-(2,3-dichlorophenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl-urea

反応条件

後処理

1. 1
   その他The product is purified by silica gel chromatography
2. 2
   洗浄eluting with a gradient of CHCl3 :EtOAc (98:2) to CHCl3 :EtOAc (1:2)

実験手順

Following the general procedure of Example 2, 0.502 g of 6-(2,3-dichlorophenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 83 was reacted with 0.206 mL of tert-butyl isocyanate. The product is purified by silica gel chromatography eluting with a gradient of CHCl3 :EtOAc (98:2) to CHCl3 :EtOAc (1:2) to afford the title compound; mp 356°-358° C.

出典