反応 #353991

反応方程式

1-[1-(4-Formylbenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril

sodium boron hydride

→

1-[1-(4-hydroxymethylbenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril

収率 77.6%

溶媒

methanol

反応条件

後処理

1. 1
   濃縮The solvent is concentrated
2. 2
   その他the resulting residue is purified by silica gel column chromatography (solvent: n-hexane:ethyl acetate=2:1)
3. 3
   その他recrystallized from n-hexane/ethanol

実験手順

1-[1-(4-Formylbenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril (500 mg) is dissolved in methanol (10 ml) and thereto is added sodium boron hydride (63 mg) under ice cooling and the mixture is stirred for 2 hours. The solvent is concentrated and the resulting residue is purified by silica gel column chromatography (solvent: n-hexane:ethyl acetate=2:1) and recrystallized from n-hexane/ethanol to give 1-[1-(4-hydroxymethylbenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril (390 mg) as white powder, m.p.: 138°-139° C.

出典