反応 #353635

反応方程式

2-(5-mercapto-1,3,4-thiadiazol-2-ylthiomethyl)saccharin

2-dimethylaminoethyl chloride hydrochloride

triethylamine

ethyl acetate

→

2-(5-[2-(N,N-dimethylamino)ethylthio]-1,3,4-thiadiazol-2-ylthiomethyl)saccharin

収率 58.0%

溶媒

DMF

反応条件

実験手順

Following a procedure similar to that described in Example 33A above, 1.72 g (0.005 mol) of 2-(5-mercapto-1,3,4-thiadiazol-2-ylthiomethyl)saccharin was reacted with 1.44 g (0.01 mol) of 2-dimethylaminoethyl chloride hydrochloride in 10 ml of DMF in the presence of 1.72 g (0.017 mol) of triethylamine to give 1.2 g (58%) of 2-(5-[2-(N,N-dimethylamino)ethylthio]-1,3,4-thiadiazol-2-ylthiomethyl)saccharin, mp 90.5°-91.5° C. (from ethyl acetate).

出典