反応 #353455

ord-6b3e2282d0434f81a4d515c4b4627bca

反応方程式

C1=COCCC1
dihydropyran
COC(=O)CCCCCN.Cl
methyl 6-aminohexanate hydrochloride
O=C(O)C(CO)NS(=O)(=O)c1ccc(Cl)cc1
(RS)-2-(4-chlorobenzenesulfonylamino)-3-hydroxypropanoic acid
COC(=O)CCCCCNC(=O)C(COC1CCCCO1)NS(=O)(=O)c1ccc(Cl)cc1
(RS)-2-(4-chlorobenzenesulfonylamino)-N-(5-methoxycarbonylpentyl)-3-(tetrahydropyran-2-yloxy)propanamide

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

The procedure described in Example 1 was repeated, except that dihydropyran (2.56 ml) and methyl 6-aminohexanate hydrochloride (3.41 g) were successively reacted with (RS)-2-(4-chlorobenzenesulfonylamino)-3-hydroxypropanoic acid (4.94 g) to obtain (RS)-2-(4-chlorobenzenesulfonylamino)-N-(5-methoxycarbonylpentyl)-3-(tetrahydropyran-2-yloxy)propanamide (0.87 g).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US05650428uspto-grants-1997_07