反応 #352846

反応方程式

tetrafluorophthalic anhydride

tri-n-octylamine

methanol

→

3,4,5,6-tetrafluorobenzoic acid methyl ester

収率 92.4%

反応条件

後処理

1. 1
   その他Into a 100 ml glass reactor equipped with a reflux condenser and a stirrer
2. 2
   その他Then, the mixture was reacted at 140° C. for 4 hours
3. 3
   その他After completion of the reaction
4. 4
   その他the reaction mixture was separated by distillation

実験手順

Into a 100 ml glass reactor equipped with a reflux condenser and a stirrer, 20 g (0.091 mol) of the tetrafluorophthalic anhydride prepared in Example 3 and 32.2 g (0.091 mol) of tri-n-octylamine were charged and 3.5 g (0.109 mol) of methanol was dropwise added thereto. Then, the mixture was reacted at 140° C. for 4 hours. After completion of the reaction, the reaction mixture was separated by distillation to obtain 17.5 g of 3,4,5,6-tetrafluorobenzoic acid methyl ester. The yield was 92.3%.

出典