反応 #351009

反応方程式

6-bromo-1-hexanol

triethylamine

acryloyl chloride

→

6-bromohexyl acrylate

収率 65.2%

溶媒

benzene

benzene

反応条件

後処理

1. 1
   workup.ADDITIONwas added dropwise
2. 2
   温度cooling with ice
3. 3
   workup.STIRRINGstirred for 3 hours
4. 4
   その他to give a reaction solution
5. 5
   洗浄The reaction solution was washed with a 3N-HCl
6. 6
   乾燥with water, dried over sodium sulfate anhydride
7. 7
   その他the solvent was evaporated
8. 8
   その他the residue was purified by the silica gel column chromatography (eluent; toluene)

実験手順

Into a reactor, 30 g of 6-bromo-1-hexanol, 18.4 g of triethylamine, and 500 ml of benzene were charged, to which a solution of 16.5 g of acryloyl chloride in 200 ml of benzene was added dropwise, while stirring and cooling with ice, and stirred for 3 hours to give a reaction solution. The reaction solution was washed with a 3N-HCl and then with water, dried over sodium sulfate anhydride, and thereafter the solvent was evaporated and the residue was purified by the silica gel column chromatography (eluent; toluene) to give 25.4 g (Y., 65.1%) of 6-bromohexyl acrylate. GC; 95.9%

出典