反応 #350757

反応方程式

2-(3,4-dimethoxybenzoyl)-4-(3,4-dihydroxycarbostyril-6-yl)thiazole

sodium boron hydride

→

2-[1-(3,4-dimethoxyphenyl)-1-hydroxymethyl]-4-(3,4-dihydroxycarbostyril-6-yl)thiazole

収率 51.8%

溶媒

chloroform

反応条件

後処理

1. 1
   workup.DISTILLATIONThe solvent was distilled off
2. 2
   抽出The residue was extracted with chloroform
3. 3
   洗浄washed
4. 4
   その他dried
5. 5
   その他subjected to solvent removal by distilation
6. 6
   その他The residue was purified by silica gel column chromatography (eluent: chloroform/methanol=99/1)
7. 7
   その他recrystallized from ethyl acetate

実験手順

In 6 ml of chloroform was dissolved 100 mg of 2-(3,4-dimethoxybenzoyl)-4-(3,4-dihydroxycarbostyril-6-yl)thiazole. Thereto was added sodium boron hydride at room temperature, and the mixture was stirred for 1 hour at the same temperature. The solvent was distilled off. The residue was extracted with chloroform. The extract was water-washed, dried and then subjected to solvent removal by distilation. The residue was purified by silica gel column chromatography (eluent: chloroform/methanol=99/1) and then recrystallized from ethyl acetate to obtain 52 mg of 2-[1-(3,4-dimethoxyphenyl)-1-hydroxymethyl]-4-(3,4-dihydroxycarbostyril-6-yl)thiazole as light brown prismatic crystals.

出典