反応 #350560

反応方程式

Ethyl 3-ketohexanoate

hydrogen

→

racemic ethyl 3-hydroxyhexanoate

収率 85.0%

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   その他the mixture was reacted
2. 2
   その他After removing the Raney nickel from the reactant
3. 3
   ろ過by filtration
4. 4
   濃縮the filtrate was concentrated
5. 5
   workup.DISTILLATIONdistilled under reduced pressure

実験手順

Ethyl 3-ketohexanoate 50 g (0.32 mol), Raney nickel 10 g and tetrahydrofuran 500 ml were mixed, and the mixture was reacted with stirring in an autoclave at a temperature of 50° C. and a hydrogen pressure of 5 kg/cm2 for 30 hours. After removing the Raney nickel from the reactant by filtration, the filtrate was concentrated and distilled under reduced pressure to obtain racemic ethyl 3-hydroxyhexanoate 42 g (0.26 mol, 85% )

出典