反応 #3502

反応方程式

water

potassium carbonate

chloromethylpropargyl ether

N-methoxybenzamide

→

N-methoxy-N-propargyloxymethylbenzamide

収率 91.9%

溶媒

acetonitrile

反応条件

後処理

1. 1
   workup.ADDITIONwas added to the reaction solution
2. 2
   抽出the mixture was extracted with ethyl acetate
3. 3
   その他The extract was dried
4. 4
   濃縮concentrated
5. 5
   その他purified by silica gel column chromatography

実験手順

0.6 g of N-methoxybenzamide was dissolved in 10 ml of acetonitrile, and 0.55 g of potassium carbonate and 0.42 g of chloromethylpropargyl ether were added thereto in this order. The mixture was stirred at room temperature for 3 hours. After completion of the reaction, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was dried, concentrated and purified by silica gel column chromatography to obtain 0.8 g of N-methoxy-N-propargyloxymethylbenzamide.

出典