反応 #349339

反応方程式

2-n-Butyl-1,2,3,4-tetrahydropyrrolo[3,4-b]indole

sodium hydride

pyrazolone

2-phenyl-5-methyl-3H-pyrazol-3-one

methyl iodide

→

4-[[2-[(n-butylmethylamino)methyl]-1H-indol-3-yl]methyl]-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one

溶媒

dimethylformamide

dimethylformamide

water

反応条件

後処理

1. 1
   その他prepared from 6.96 g
2. 2
   その他at 10°-20° C
3. 3
   温度The mixture is heated on a steam bath for one hour
4. 4
   その他precipitating the product, 8.6 g
5. 5
   その他Recrystallization from methanol
6. 6
   その他gives 6.3 g

実験手順

A solution of 2-n-Butyl-1,2,3,4-tetrahydropyrrolo[3,4-b]indole, 8.6 g., and methyl iodide, 2.6 ml. in dimethylformamide is stirred fifteen minutes, and then added all at once to a solution of the anion of the pyrazolone, prepared from 6.96 g. of 2-phenyl-5-methyl-3H-pyrazol-3-one and 2.0 g. fifty percent sodium hydride in dimethylformamide at 10°-20° C. The mixture is heated on a steam bath for one hour, then stirred at room temperature for sixteen hours. The reaction mixture is next poured into water, precipitating the product, 8.6 g., m.p. about 180°-200° with decomposition. Recrystallization from methanol gives 6.3 g., m.p. 195°-200° with decomposition.

出典