反応 #3493

反応方程式

3-methylindene-2-carboxylic acid

thionyl chloride

→

3-methylindene-2-oyl chloride

反応条件

後処理

1. 1
   その他Careful removal of the solvent
2. 2
   workup.DISTILLATIONby distillation under reduced pressure

実験手順

1.0 g of 3-methylindene-2-carboxylic acid and 5 ml thionyl chloride were refluxed for 4 hours. Careful removal of the solvent by distillation under reduced pressure gave 3-methylindene-2-oyl chloride. The acid chloride dissolved in THF was dropped into a mixture of guanidine and sodium hydroxide at room temperature over a period of 10 min. and stirred for one hour. The reaction was terminated by work-up and the product was purified by column chromatography.

出典