反応 #349098

反応方程式

5-bromovaleric acid

triphenylphosphine

acetonitrile

→

4-carboxybutyltriphenylphosphonium bromide

溶媒

benzene

反応条件

後処理

1. 1
   workup.ADDITIONA mixture of 103 g
2. 2
   温度cooled
3. 3
   workup.ADDITIONdiluted with 100 ml
4. 4
   その他to crystallize
5. 5
   ろ過The crystals are filtered
6. 6
   洗浄washed with benzene and ether
7. 7
   その他to yield colorless material, m.p. 207°-209° C.

実験手順

A mixture of 103 g. of 5-bromovaleric acid and 152 g. of triphenylphosphine in 400 ml. of acetonitrile is refluxed for 48 hours, cooled, diluted with 100 ml. of benzene and allowed to crystallize. The crystals are filtered, washed with benzene and ether, to yield colorless material, m.p. 207°-209° C.

出典