反応 #348651

反応方程式

hydrogen

2,3-dihydro-1'-benzylspiro[benzofuran-2,4'-piperidine]

→

2,3-dihydrospiro[benzofuran-2,4'-piperidine]

溶媒

—

benzene-ether

isopropyl alcohol

反応条件

後処理

1. 1
   ろ過filtered
2. 2
   濃縮concentrated to dryness
3. 3
   その他leaving a white solid
4. 4
   ろ過the solution filtered through celite
5. 5
   濃縮concentrated again
6. 6
   その他providing a white solid, which upon trituration with ether

実験手順

A solution of 5.3 g of 2,3-dihydro-1'-benzylspiro[benzofuran-2,4'-piperidine], free base of B, in 250 ml of isopropyl alcohol is hydrogenated with a Paar shaker, 50 psig, 65°-70° C. and 1 g of a 10% palladium/carbon catalyst until the uptake of hydrogen is completed. Thereafter, the solution is successively permitted to cool to ambient temperature, filtered and concentrated to dryness, leaving a white solid. The solid is dissolved in a benzene-ether mixture, the solution filtered through celite and then concentrated again providing a white solid, which upon trituration with ether, provides the product, 2,3-dihydrospiro[benzofuran-2,4'-piperidine], mp 56°-58.5° C.

出典