反応 #348500

反応方程式

N-benzyloxycarbonyl-L-aspartic acid

L-phenylalanine methyl ester

→

N-benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester

L-phenylalanine methyl ester

収率 95.5%

溶媒

反応条件

後処理

1. 1
   その他The precipitate was collected
2. 2
   洗浄washed with water
3. 3
   その他dried

実験手順

A 267.2 mg (1 m mol) of N-benzyloxycarbonyl-L-aspartic acid and 537.6 mg (3 m mol) of L-phenylalanine methyl ester were dissolved in 5 ml of McIlvain's buffer solution (pH:7.0). The resulting solution was admixed with 100 mg of Thermoase and 100 mg of potato inhibitor and shaken at 38° C. for 20 hours. The precipitate was collected and washed with water and dried to obtain 580 mg of a crude crystalline addition compound of N-benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester and L-phenylalanine methyl ester (1:1) (melting point: 123 to 125° C.; Yield: 95.5 % based on N-benzyloxycarbonyl-L-aspartic acid).

出典