反応 #3485

反応方程式

[[3-(Aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]amino]acetic acid methyl ester

NaOH

MeOH

HCl

→

[[3-(Aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]amino]acetic acid

収率 53.0%

溶媒

EtOAc

反応条件

後処理

1. 1
   温度was refluxed 0.33 hour
2. 2
   温度cooled
3. 3
   洗浄the EtOAc layer was washed with brine
4. 4
   乾燥dried over MgSO4
5. 5
   その他evaporated in vacuo
6. 6
   その他The residue was crystallized from MeOH

実験手順

A mixture of 190 mg (0.48 mmol) of [[3-(Aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]amino]acetic acid methyl ester, 5 ml of 1N NaOH, and 15 ml of MeOH was refluxed 0.33 hour, cooled, and stirred at room temperature for 1 hour. EtOAc and aqueous HCl were added and the EtOAc layer was washed with brine, dried over MgSO4, and evaporated in vacuo. The residue was crystallized from MeOH to give 96 mg (53%) of [[3-(Aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]amino]acetic acid melting at 151°-157° C.

出典