反応 #347789

反応方程式

sodium chloride

5-bromopentanonitrile

dibenzylamine

N,N-diisopropylethylamine

→

oil

収率 108.9%

5-(N,N-Dibenzylamino)pentanonitrile

収率 108.9%

溶媒

water

dimethylformamide

dimethylformamide

反応条件

後処理

1. 1
   温度to cool
2. 2
   抽出the mixture was extracted with ether (2×200 ml)
3. 3
   乾燥The extracts were dried (Na2SO4)
4. 4
   濃縮concentrated in vacuo

実験手順

A solution of 5-bromopentanonitrile (16.20 g) in dry dimethylformamide (100 ml) was added dropwise over 15 minutes to a stirred solution of dibenzylamine (19.73 g) and N,N-diisopropylethylamine (35 ml, 26 g) in dry dimethylformamide (100 ml). The solution was heated (oil bath 110° C.) for 4 hours and was allowed to cool. The solution was poured onto a mixture of saturated aqueous sodium chloride (400 ml) and water (400 ml) and the mixture was extracted with ether (2×200 ml). The extracts were dried (Na2SO4) and concentrated in vacuo to give a mobile oil (30.32 g).

出典