反応 #347330

反応方程式

Sodium dithionite

5-nitroso-2,4-diamino-6-benzyloxy-primidine

5-nitroso-2, 4-diamino-6-benzyloxy-primidine

→

2,4,5-triamino-6-benzyloxy-pyrimidine

溶媒

H2O

反応条件

後処理

1. 1
   その他The free base is separated out
2. 2
   workup.ADDITIONby adding aqueous ammonia
3. 3
   温度The crude product is cooled
4. 4
   その他crystallized from water, to which activated charcoal
5. 5
   workup.ADDITIONa trace of sodium dithionite is added
6. 6
   その他yielding 9

実験手順

Sodium dithionite is added in portions to a suspension of 17 g 5-nitroso-2,4-diamino-6-benzyloxy-primidine (8) in 300 mL H2O at 50° C. until the red nitroso compound is fully reduced. The free base is separated out by adding aqueous ammonia. The crude product is cooled, suctioned off and crystallized from water, to which activated charcoal and a trace of sodium dithionite is added yielding 9.

出典