反応 #346679

反応方程式

4-CHLORO-5-METHYLPHENOL

2-SULFO-4-CHLORO-5-METHYLPHENOL

sulfuric acid

2-SULFO-4,6-DICHLORO-5-METHYLPHENOL

NITRIC ACID

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2-NITRO-4,6-DICHLORO-5-METHYLPHENOL

2-sulfo-4-chloro-5-methylphenol

反応条件

実験手順

2-NITRO-4,6-DICHLORO-5-METHYLPHENOL IS PREPARED BY THE SULFONATION OF 4-CHLORO-5-METHYLPHENOL TO FORM 2-SULFO-4-CHLORO-5-METHYLPHENOL WHICH IS CHLORINATED TO 2-SULFO-4,6-DICHLORO-5-METHYLPHENOL WHICH IS IN TURN REACTED WITH NITRIC ACID TO FORM THE DESIRED PRODUCT. The sulfonation is carried out with concentrated sulfuric acid at elevated temperatures to form 2-sulfo-4-chloro-5-methylphenol. Thereafter the reaction mixture is diluted with water to a sulfuric acid content of 20-30%. The resulting 2-sulfo-4-chloro-5-methylphenol is chlorinated with chlorine at elevated temperature and normal or elevated pressures to form 2-sulfo-4,6-dichloro-5-methylphenol which is then reacted with nitric acid.

出典