反応 #346354

反応方程式

2,2,2-trichloroethyl 6-(2-phenylacetamido)-2,2-dimethylpenam-3-carboxylate

acetic acid

sodium percarbonate

acetic acid

→

2,2,2-trichloroethyl 6-(2-phenylacetamido)-2,2-dimethylpenam-3-carboxylate-1-oxide

溶媒

water

water

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   温度while cooling in an ice bath
3. 3
   workup.STIRRINGThe mixture was stirred for 3 hours
4. 4
   ろ過The precipitate was collected by filtration
5. 5
   洗浄washed with water
6. 6
   その他dried

実験手順

2,2,2-trichloroethyl 6-(2-phenylacetamido)-2,2-dimethylpenam-3-carboxylate (466 mg.) was added to acetic acid (2 cc), and sodium percarbonate (377 mg.) was added thereto while cooling in an ice bath. The mixture was stirred for 30 minutes, and sodium tungstate dihydrate (40 mg.), acetic acid (1 cc) and water (1 cc) were added thereto. The mixture was stirred for 3 hours, and then water (50 cc) was added thereto. The precipitate was collected by filtration, washed with water and dried to yield crude crystals (400 mg.) of 2,2,2-trichloroethyl 6-(2-phenylacetamido)-2,2-dimethylpenam-3-carboxylate-1-oxide, m.p. 165° - 167° C.

出典