反応 #3456

反応方程式

4-hydroxy-2-methyl-1-[(1-naphthalenyl)methyl]-1H-indole

NaH

methyl bromoacetate

→

[[2-methyl-1-[(1-naphthalenyl)methyl]-1H-indol-4-yl]oxy]acetic acid methyl ester

反応条件

後処理

1. 1
   その他The product was purified by chromatography over silica gel eluting with 20% EtOAc/hexane

実験手順

Using the procedure described in Example 1, Part E, 4-hydroxy-2-methyl-1-[(1-naphthalenyl)methyl]-1H-indole (796 mg, 2.8 mmol) was treated with 112 mg (2.8 mmol) of 60% NaH/mineral oil and then 0.27 mL (0.27 mmol) of methyl bromoacetate. The product was purified by chromatography over silica gel eluting with 20% EtOAc/hexane to give 450 mg (45% yield) of [[2-methyl-1-[(1-naphthalenyl)methyl]-1H-indol-4-yl]oxy]acetic acid methyl ester, 167°-171° C.

出典