反応 #344864

反応方程式

N-(2,6-diphenyl-3,5-dimethylpiperidin-4-yl)lauramide

dimethyldioxirane

→

title compound

N-(1-Hydroxy-2,6-diphenyl-3,5-dimethylpiperidin-4-yl)lauramide

溶媒

acetone

反応条件

実験手順

Following the general procedure of Example 2 and using 8.56 g (18.5 mmol) of N-(2,6-diphenyl-3,5-dimethylpiperidin-4-yl)lauramide, prepared in Example 11, and 462 ml of a 0.04 molar solution of dimethyldioxirane (18.5 mmol) in acetone, the title compound is isolated in a yield of 7.37 g (70%) after purification by LC (silica gel; ethyl acetate:hexanes) as a white solid melting at 58°-62° C.

出典