反応 #344036

反応方程式

rac-3,4-dihydro-2-ethynyl-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol

1-iodonaphthalene

→

rac-3,4-dihydro-2,5,7,8-tetramethyl-2-[(1-naphthyl)ethynyl]-2H-1-benzopyran-6-ol

溶媒

methylene chloride

反応条件

後処理

1. 1
   その他It was isolated by chromatography over 40 fold amount of silica gel
2. 2
   その他The combined clean fractions were crystallized from hexane
3. 3
   その他recrystallized from petroleum ether
4. 4
   その他to give colorless crystals with m.p. 127°-128°

実験手順

rac-3,4-dihydro-2,5,7,8-tetramethyl-2-[(1-naphthyl)ethynyl]-2H-1-benzopyran-6-ol was prepared by coupling rac-3,4-dihydro-2-ethynyl-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol with 1-iodonaphthalene under the conditions described in Example 1. It was isolated by chromatography over 40 fold amount of silica gel using methylene chloride. The combined clean fractions were crystallized from hexane and recrystallized from petroleum ether to give colorless crystals with m.p. 127°-128°.

出典