反応 #343980

反応方程式

2-hydroxyoctanoic acid

decyl alcohol

→

clear pale yellow liquid

収率 77.3%

Decyl 2-Hydroxyoctanoate

収率 77.3%

溶媒

反応条件

後処理

1. 1
   温度The mixture was heated to 140° for 8 hours
2. 2
   その他water was collected as the reaction
3. 3
   洗浄by washing three times with 50 ml saturated sodium bicarbonate solution
4. 4
   その他The organic layer was collected
5. 5
   乾燥dried over magnesium sulfate
6. 6
   その他Excess decyl alcohol was removed by high vacuum distillation

実験手順

A 250 ml one neck round bottom flask equipped with a Dean Stark trap, condenser and nitrogen inlet/outlet was charged with 20.0 g (0.125 moles) 2-hydroxyoctanoic acid, 79.0 g (0.499 moles) decyl alcohol, and 0.062 g sulfuric acid. The mixture was heated to 140° for 8 hours and water was collected as the reaction proceeded. The acid was neutralized by washing three times with 50 ml saturated sodium bicarbonate solution. Approximately 50 ml ether was needed to break the emulsion. The organic layer was collected and dried over magnesium sulfate. Excess decyl alcohol was removed by high vacuum distillation to yield 28.99 g (77.3% yield) of clear pale yellow liquid. According to GC the product is 99.6% pure.

出典