反応 #343979

反応方程式

DL-2-hydroxycaproic acid

decyl alcohol

→

clear colorless liquid

収率 49.0%

Decyl 2-Hydroxyhexanoate

収率 49.0%

溶媒

反応条件

後処理

1. 1
   その他water collected as the reaction
2. 2
   洗浄by washing three times with 50 ml saturated sodium bicarbonate solution
3. 3
   その他The organic layer was collected
4. 4
   乾燥dried over magnesium sulfate
5. 5
   その他Excess decyl alcohol was removed by high vacuum distillation

実験手順

A 50 ml one neck round bottom flask equipped with a Dean Stark trap, condenser and a nitrogen inlet/outlet was charged with 5.0 g (0.038 moles) DL-2-hydroxycaproic acid, 23.95 g (0.151 moles) decyl alcohol, and 0.019 g sulfuric acid. The reactants were heated to 140° C. for 8 hours and water collected as the reaction proceeded. The acid was neutralized by washing three times with 50 ml saturated sodium bicarbonate solution. Approximately 50 ml ether was needed to break the emulsion. The organic layer was collected and dried over magnesium sulfate. Excess decyl alcohol was removed by high vacuum distillation to yield 4.34 g (49% yield) of clear colorless liquid. According to GC the product is 95.74% pure.

出典