反応 #343693

ord-083540e260744b8b94717887f3bd53ce

反応方程式

O=P([O-])(O)O.[K+]
potassium dihydrogenphosphate
OC[C@H]1O[C@@H](n2cnc3c(O)ncnc32)[C@H](O)[C@@H]1O
inosine
c1c[nH]nn1
triazole
O=c1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1
uridine
Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1
cytidine
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
adenosine
NC(=O)c1nc[nH]n1
1, 2, 4-triazole-3-carboxamide
Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1
guanosine
→
NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)n1
ribavirin

反応物

—
solution
O=P([O-])(O)O.[K+]
potassium dihydrogenphosphate
OC[C@H]1O[C@@H](n2cnc3c(O)ncnc32)[C@H](O)[C@@H]1O
inosine
c1c[nH]nn1
triazole
O=c1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1
uridine
Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1
cytidine
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
adenosine
—
saccharide
NC(=O)c1nc[nH]n1
1, 2, 4-triazole-3-carboxamide
Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1
guanosine

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

By using a substrate solution (pH 6.0) containing 40 mM 1, 2, 4-triazole-3-carboxamide (hereinafter called "triazole") as the base donor, 40 mM uridine, inosine, cytidine, adenosine or guanosine as the saccharide residue donor and 40 mM potassium dihydrogenphosphate, ribavirin was produced in the same manner as in Example 1. The results are shown in Table 7.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US05258301uspto-grants-1993_11