反応 #343469

反応方程式

water

4-methylphenylsulfonyl chloride

tetrahydrothiophene-3-ol

4-methylphenylsulfonyl chloride

→

product

収率 50.6%

3-Tetrahydrothienyl 4-methylphenylsulfonate

収率 50.6%

溶媒

pyridine

反応条件

後処理

1. 1
   温度to warm to room temperature
2. 2
   workup.STIRRINGwas stirred for 1 hour
3. 3
   workup.STIRRINGthe reaction mixture was stirred at room temperature for 64 hours
4. 4
   抽出the whole was extracted with methylene chloride
5. 5
   乾燥The methylene chloride solution was dried
6. 6
   濃縮concentrated

実験手順

To a chilled solution of 1.12 g (0.0098 mole) of tetrahydrothiophene-3-ol in 15 mL of pyridine was added 1.91 g (0.01 mole) of 4-methylphenylsulfonyl chloride, and the reaction mixture was stirred in the cold, about 16° C., for 1 hour then placed in a cold refrigerator for 16 hours. The reaction mixture was allowed to warm to room temperature and was stirred for 1 hour. An additional 0.3 g (0.0016 mole) of 4-methylphenylsulfonyl chloride was added, and the reaction mixture was stirred at room temperature for 64 hours. The reaction mixture was poured into water, and the whole was extracted with methylene chloride. The methylene chloride solution was dried and concentrated to give 1.28 g of product as an oil.

出典