反応 #343467

反応方程式

tetrahydro-4H-thiopyran-4-ol

4-methylphenylsulfonyl chloride

water

→

product

収率 142.0%

Tetrahydro-4H-thiopyran-4-yl 4-methylphenylsulfonate

収率 142.0%

溶媒

pyridine

反応条件

後処理

1. 1
   抽出the whole extracted with diethyl ether
2. 2
   洗浄The organic phase was washed with water
3. 3
   乾燥with a 10% aqueous solution of sodium hydroxide, dried
4. 4
   濃縮concentrated

実験手順

To a solution of 4.1 g (0.015 mole) of tetrahydro-4H-thiopyran-4-ol in 40 mL of pyridine, cooled in an ice bath, was added 2.90 g (0.15 mole) of 4-methylphenylsulfonyl chloride, and the reaction mixture was stirred at room temperature for 16 hours. The mixture was poured into a mixture of ice and water, and the whole extracted with diethyl ether. The organic phase was washed with water then with a 10% aqueous solution of sodium hydroxide, dried, and concentrated to give 5.8 g of product as an oil.

出典