反応 #343041

反応方程式

2-amino-5-methylbenzoic acid

2-(2-amino-5-methylphenyl)propene

methyl 2-amino-5-methylbenzoate

(2-amino-5-methylphenyl)dimethylcarbinol

4,6-dimethylcinnoline

6-methyl-4-(trichloromethyl)cinnoline

2-amino-3-methylbenzoic acid

→

6-Methylcinnoline-4-carboxylic acid

反応条件

実験手順

51 was prepared, as a tan solid, m.p.: 179°-180° C., from 2-amino-5-methylbenzoic acid, by the respective procedures described in Example 49 for preparing 49 from 2-amino-3-methylbenzoic acid: via methyl 2-amino-5-methylbenzoate (a solid, m.p.: 62°-63° C.), (2-amino-5-methylphenyl)dimethylcarbinol (an oil, b.p.: 100° C./0.1 Torr.), 2-(2-amino-5-methylphenyl)propene (a liquid, b.p.: 87°-90° C./0.5 Torr.), 4,6-dimethylcinnoline (a solid, m.p.: 75°-76° C.), and 6-methyl-4-(trichloromethyl)cinnoline (green crystals, m.p.: 132°-133° C., with decomposition).

出典