反応 #343003

反応方程式

hydrochloric acid

sulfonamide

2-[5-(Methylthio)-1,3,4-oxadiazol-2-yl]benzenemethanesulfonamide

phenyl (4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamate

DBU

→

subject compound

収率 28.5%

N-[(4-Methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-[5-(methylthio)-1,3,4-oxadiazol-2-yl]benzenemethanesulfonamide

収率 28.5%

溶媒

water

p-dioxane

反応条件

後処理

1. 1
   ろ過filtration
2. 2
   洗浄the residue was washed with 1×5 ml of warm ethyl acetate

実験手順

By the procedure of Example 4, 0.62 g of the sulfonamide of Example 3 was reacted with 0.57 g of phenyl (4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamate and 0.33 g of DBU in 10 ml of p-dioxane. After stirring two hours at room temperature the solution was diluted with about 75 ml of water and acidified with concentrated hydrochloric acid (red to litmus). Following filtration, the residue was washed with 1×5 ml of warm ethyl acetate to give 0.28 g of the subject compound; m.p. 175°-177° C.

出典