反応 #342684

反応方程式

water

6-acetyl-7-hydroxy-1-phenylmethyl-4(1H)-quinolinone

potassium carbon- ate

3-bromopropene

→

quino- lone

収率 198.7%

溶媒

dimethylformamide

反応条件

後処理

1. 1
   その他The solid produced
2. 2
   ろ過was filtered off
3. 3
   洗浄washed well with water
4. 4
   その他The yellow solid was dried

実験手順

A mixture of 6-acetyl-7-hydroxy-1-phenylmethyl-4(1H)-quinolinone (6.3 g, 21.5 mmol), anhydrous potassium carbon- ate (2.97 g, 21.5 mmol) and 3-bromopropene (2.86 g, 2.36 mmol) was stirred at room temperature in dry dimethylformamide (100 ml) for 18 hours. The mixture was poured into a large excess of water and was stirred rapidly for 1 hour. The solid produced was filtered off and washed well with water. The yellow solid was dried to give the required quino- lone as a yellow powder 6.2 g (87%) mp 139°-140°.

出典