反応 #342000

反応方程式

ethyl 4-bromo-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylate

potassium hydroxide

→

title compound

収率 97.2%

4-bromo-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid

収率 97.2%

溶媒

methanol

反応条件

後処理

1. 1
   温度The resulting solution was cooled down to room temperature
2. 2
   その他evaporated the volatile solvent
3. 3
   ろ過filtered
4. 4
   その他The filtrated solid was dried under vacuum

実験手順

To a solution of ethyl 4-bromo-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylate (3.5 g, 7.37 mmol) in methanol (50 ml) at room temperature was added potassium hydroxide (830 mg, 14.8 mmol) in one portion. The reaction mixture was warmed to 100° C. and then stirred for 5 hours. The resulting solution was cooled down to room temperature and then evaporated the volatile solvent. The residue was acidified with 10% hydrochloric acid and then filtered using water and hexane. The filtrated solid was dried under vacuum to obtain the title compound (3.2 g, 97%) as pale yellow solid.

出典