反応 #341012

ord-42413c4a7e34491691d852880f4c14c4

反応方程式

C[C@H]1CC[C@H](N(C(=O)Nc2ncc(C=O)s2)C2CCCCCC2)CC1
trans-1-cycloheptyl-3-(5-formyl-thiazol-2-yl)-1-(4-methyl-cyclohexyl)-urea
COC(=O)CCS(=O)(=O)N1CC[NH2+]CC1.[Cl-]
4-(2-methoxycarbonyl-ethanesulfonyl)-piperazin-1-ium chloride
→
COC(=O)CCS(=O)(=O)N1CCN(Cc2cnc(NC(=O)N(C3CCCCCC3)[C@H]3CC[C@H](C)CC3)s2)CC1
Trans-3-(4-{2-[3-cycloheptyl-3-(4-methyl-cyclohexyl)-ureido]-thiazol-5-ylmethyl}-piperazine-1-sulfonyl)-propionic acid methyl ester

反応物

C[C@H]1CC[C@H](N(C(=O)Nc2ncc(C=O)s2)C2CCCCCC2)CC1
trans-1-cycloheptyl-3-(5-formyl-thiazol-2-yl)-1-(4-methyl-cyclohexyl)-urea
COC(=O)CCS(=O)(=O)N1CC[NH2+]CC1.[Cl-]
4-(2-methoxycarbonyl-ethanesulfonyl)-piperazin-1-ium chloride

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他Prepared in 65% (380 mg)
  2. 2
    その他yield

実験手順

Prepared in 65% (380 mg) yield as described in general procedure (B) from trans-1-cycloheptyl-3-(5-formyl-thiazol-2-yl)-1-(4-methyl-cyclohexyl)-urea (364 mg, 1.0 mmol) and 4-(2-methoxycarbonyl-ethanesulfonyl)-piperazin-1-ium chloride (273 mg, 1 mmol).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07872139B2uspto-grants-2011_01