反応 #340897

反応方程式

dihydrofinasteride

HCl

methanol

→

3-oxo-4-aza-5α-androstane-17β-carboxylic acid

反応条件

後処理

1. 1
   温度are heated
2. 2
   温度to reflux
3. 3
   温度on heating
4. 4
   workup.WAITafter 8 hours
5. 5
   ろ過can be readily filtered
6. 6
   洗浄The filtercake is washed three times intensively with 100 g each time of water
7. 7
   その他suction-dried for approx. 15 minutes and subsequently dried overnight

実験手順

A suspension of 100 g (0.26 mol) of dihydrofinasteride, 480 g of 20% HCl solution (2.63 mol) and 120 g of methanol are heated to reflux and boiled intensively for 8-12 hours. The reactant goes into solution on heating; after 8 hours, there is a suspension which can be readily filtered. The filtercake is washed three times intensively with 100 g each time of water, suction-dried for approx. 15 minutes and subsequently dried overnight. Yield: 60 g.

出典