反応 #340704

反応方程式

1-chloro-2-methylpropyl methylformate

sodium methanethiolate

→

title compound ( 6a )

1-Chloro-2-methylpropyl methylthioformate

溶媒

dichloromethane

water

dichloromethane

dichloromethane

反応条件

後処理

1. 1
   その他to separate
2. 2
   洗浄washed with water and brine
3. 3
   乾燥dried with anhydrous sodium sulfate (Na2SO4)
4. 4
   その他After rotary evaporation
5. 5
   その他to remove the solvent

実験手順

To a stirred solution of 1-chloro-2-methylpropyl methylformate in dichloromethane (DCM) was added a solution of sodium methanethiolate (CH3—SNa) (1.0 eq.) in water at 0° C. and 0.02 eq. of tetrabutylammonium bromide. The reactants were stirred at 0° C. for 30 min and then diluted with dichloromethane (DCM). The dichloromethane layer was allowed to separate, then washed with water and brine, and dried with anhydrous sodium sulfate (Na2SO4). After rotary evaporation to remove the solvent, the title compound (6a) was obtained. 1H-NMR (CDCl3): δ 1.05 (d, J=5.6 Hz, 3H), 1.07 (d, J=5.6 Hz, 3H), 2.18 (m, 1H), 2.38 (s, 3H), 6.34 (d, J=5.6 Hz, 1H) ppm.

出典