反応 #340652

反応方程式

(6-bromo-1H-pyrrolo[2,3-b]pyridin-1-yl)(phenyl)methanone

2—(6-bromo-1H-pyrrolo[2,3-b]pyridin-1-yl)(phenyl)methanone

→

6-bromo-1H-pyrrolo[2,3-b]pyridine

溶媒

dioxane

KOH

反応条件

後処理

1. 1
   その他had been consumed (2 to 4 hours)
2. 2
   workup.ADDITIONThe reaction was diluted with 50 mL of ethyl acetate
3. 3
   洗浄washed with 2×25 mL of NaHCO3 (aq. satd.) and 25 mL of brine
4. 4
   乾燥The organic layer was dried with sodium sulfate
5. 5
   その他evaporated
6. 6
   その他purified by column chromatography
7. 7
   その他gave approximately 65% overall yield

実験手順

(6-bromo-1H-pyrrolo[2,3-b]pyridin-1-yl)(phenyl)methanone 155 was dissolved in 20 mL of dioxane and 20 mL of 2M KOH (aq). This was stirred at ambient temperature until analysis indicated all of the starting material had been consumed (2 to 4 hours). The reaction was diluted with 50 mL of ethyl acetate and washed with 2×25 mL of NaHCO3 (aq. satd.) and 25 mL of brine. The organic layer was dried with sodium sulfate, evaporated and purified by column chromatography. Combined steps 2 and 3 gave approximately 65% overall yield.

出典