反応 #339927

反応方程式

Ammonia

2,4-dichloro-6-piperidin-1-yl-[1,3,5]triazine

→

title compound 221

収率 98.0%

2-Amino-4-chloro-6-piperidin-1-yl-[1,3,5]triazin

収率 98.0%

溶媒

1,4-dioxane

反応条件

後処理

1. 1
   温度to cool to room temperature
2. 2
   その他partitioned between AcOEt
3. 3
   その他After separation
4. 4
   洗浄the organic layer was washed with water and brine
5. 5
   乾燥dried over anhydrous Na2SO4
6. 6
   ろ過filtered
7. 7
   濃縮concentrated

実験手順

Ammonia was bubbled for 5 min in a solution of 2,4-dichloro-6-piperidin-1-yl-[1,3,5]triazine (500 mg, 2.15 mmol) in dry 1,4-dioxane (20 mL). The solution was heated at 70° C. for 16 h in a sealed tube. The reaction mixture was allowed to cool to room temperature, and partitioned between AcOEt and a solution of sat. NH4Cl. After separation, the organic layer was washed with water and brine, dried over anhydrous Na2SO4, filtered and concentrated to afford the title compound 221 (453 mg, 2.12 mmol, 98% yield). LRMS: [MH]=214.1.

出典