反応 #339873

反応方程式

hydrochloric acid

sodium boron hydride

water

methyl 2-hydroxy-3,3,3-trifluoro-2-trifluoromethylpropionate

→

3,3,3-trifluoro-2-trifluoromethyl-1,2-propane diol

収率 96.0%

溶媒

diethyl ether

反応条件

後処理

1. 1
   workup.STIRRINGThe mixture was stirred for 10 hours
2. 2
   その他to quench
3. 3
   その他the reaction
4. 4
   その他An organic layer was separated from the reaction mixture
5. 5
   濃縮concentrated
6. 6
   workup.DISTILLATIONdistilled

実験手順

To a mixture of 25.0 g of sodium boron hydride, 500 g of water, and 500 g of diethyl ether, with stirring, 100 g of methyl 2-hydroxy-3,3,3-trifluoro-2-trifluoromethylpropionate was added dropwise. The mixture was stirred for 10 hours, after which hydrochloric acid was added to quench the reaction. An organic layer was separated from the reaction mixture, concentrated, and distilled, obtaining 83.9 g of 3,3,3-trifluoro-2-trifluoromethyl-1,2-propane diol (yield 96%).

出典