反応 #338967

反応方程式

2-(2-aminoethoxy)ethanol

9-anthracenemethanol

4-nitrophenyl chloroformate

triethylamine

→

[2-(2-Hydroxy-ethoxy)-ethyl]-carbamic acid anthracen-9-ylmethyl ester

溶媒

CH2Cl2

CH2Cl2

反応条件

後処理

1. 1
   workup.STIRRINGstirring
2. 2
   workup.WAITcontinued for another 24 hours
3. 3
   洗浄was then washed with a 2% sodium hydroxide (w/w) solution until no p-nitrophenol
4. 4
   乾燥The dichloromethane was dried with sodium sulfate
5. 5
   ろ過filtered
6. 6
   その他evaporated under reduced pressure

実験手順

To a stirring slurry of 9-anthracenemethanol (10 g, 48 mmol) and 4-nitrophenyl chloroformate (13.6 g, 67.5 mmol) in 200 ml CH2Cl2 was added triethylamine (6.7 ml, 0.19 mol). The resulting gold colored solution was allowed to stir 16 hrs at room temperature. At this point, 2-(2-aminoethoxy)ethanol (14.4 ml, 0.144 mol) was added and stirring continued for another 24 hours. The CH2Cl2 reaction mixture was then washed with a 2% sodium hydroxide (w/w) solution until no p-nitrophenol was observed in the organic layer. The dichloromethane was dried with sodium sulfate, filtered, and evaporated under reduced pressure.

出典